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Cayman Chemical Cel-Based asy nutrophIl I 25mL
Supplier: Cayman Chemical 60061225 ML
An ionizable cationic lipid (pKa 6.5) has been used in the generation of LNPs for the delivery of mRNA and anticancer agents in vivo LNPs containing DMT7 and encapsulating mRNA encoding Il-12 and MSA-2 decrease tumor volume lung metastatic nodule numbers and lung levels of CD4 and CD8 T cells in a 4T1 breast cancer mouse xenograft model of lung metastasis the same LNPs decrease the number of Tregs increase the number of tumor-associated M1 macrophages and increase intratumoral levels of Il-12 Il-2 Tnf-a and Ifn-? in a B16/F10 murine melanoma model
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