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Cayman Chemical Cel-Based asy nxIn V BI 50mL
Supplier: Cayman Chemical 60030250 ML
A TRPV4 and TRPA1 inhibitor (IC50s 4.19 and 5.56 respectively for the rat channels) inhibits GSK1016790A-induced calcium influx in whole-cell patch-clamp assays using Neuro2a cells expressing TRPV4 at 5 UM prevents compression-induced increases in NF-KB transcriptional activity and secreted levels of IL-6 and VEGFA as well as inhibits compression-induced fractures abnormal cell morphology and fissures in the intervertebral space in primary mouse lumbar spines at 10 UM
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