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Medchemexpress LLC Celgosivir (hydrochloride) | 141117-12-6 | 295.76 | 25 MG
Supplier: Medchemexpress LLC 25MGHY16134A
Celgosivir hydrochloride is an α-glucosidase I inhibitor that inhibits bovine viral diarrhoea virus (BVDV) with an IC50 of 1.27 μM in in vitro assay. It exhibits potent antiviral activity and protection in various models.
- More effective than the parent molecule at causing accumulation of glucosylated oligosaccharides in HIV-infected cells.
- Exhibits potent antiviral activity against HIV-1 with an IC50 of 2.0±2.3 μM.
- Inhibits BVDV with IC50 values of 16 and 47 μM in plaque assay and cytopathic effect assay, respectively.
- Inhibits DENV2 replication with an EC50 of 0.2 μM, and DENV1, 3 and 4 at less than 0.7 μM.
- Fully protects AG129 mice from lethal infection with a mouse adapted dengue virus.
- Protection is dose- and schedule-dependent in animal models.
- Pharmacokinetics studies show rapid metabolization to castanospermine in mice.
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