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Cayman Chemical Centpeda mnma Brevln A 10mg
Supplier: Cayman Chemical 3399310 MG
A sesquiterpene lactone with anticancer activity; an inhibitor of STAT3 signaling (IC50 = 10.6 µM in A549R cells); inhibits the tyrosine kinase activity of the JAK1, JAK2, JAK3, and JAK4 JH1 subunit (IC50s = 11.2, 8.4, 10.2, and 11.9 µM, respectively); inhibits proliferation of a variety of cancer cells in a concentration-dependent manner; decreases the mitochondrial membrane potential, induces apoptosis, and increases ROS levels in CT26 cells; induces autophagosome formation in a PI3K-dependent manner; increases intratumor expression of LC3-II and reduces tumor growth in a murine CT26 colon cancer model at 5 mg/kg per day
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