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Cayman Chemical CeralIfImod 10mg
SDP

Supplier:  Cayman Chemical 2415910 MG

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An agonist of S1P1 and S1P5 receptors (Kis = 0.626 and 0.574 nM, respectively); selective for S1P1 and S1P5 over S1P2-4 (Kis = >5,450, >5,630, and 28.8 nM, respectively); induces calcium influx in CHO-K1 cells overexpressing S1P1 (EC50 = 1 nM) and cAMP accumulation in CHO-K1 cells overexpressing S1P1 or S1P5 (EC50s = 0.027 and 0.33 nM, respectively); reduces paw edema in a rat model of CIA at 0.03 and 0.1 mg/kg; delays disease onset and inhibits lymphocyte infiltration of the spinal cord in a rat model of EAE; prevents disease relapse in a non-obese diabetic mouse model of relapsing-remitting EAE

Catalog No. 50-293-6892


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