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Bachem (Val34)-Amyloid Beta Protein (1-40) Trifluoroacetate
Supplier: Bachem 4089805.1000
(Val34)-Amyloid Beta Protein (1-40) Trifluoroacetate, H-Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Val-Met-Val-Gly-Gly-Val-Val-OH, 1678415-83-2, C193H293N53O58S, Mr 4315.84, 1mg. Amyloid b-Protein (1-40) L34V, Amyloid b-Protein (1-40) Piedmont Mutation. Cerebral amyloid angiopathy (CAA) is a common finding in Alzheimer’s disease in which amyloid-Ab vascular deposits are featured in >80% of the cases. Mutations in the positions 21-23 (e.g. Dutch mutation E22Q) are primarily associated with CAA, although they manifest with strikingly different clinical phenotypes: cerebral hemorrhage or dementia. The Piedmont L34V Ab mutant, located outside this hot spot, shows a similar hemorrhagic phenotype, albeit less aggressive than the widely studied Dutch variant.
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