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Medchemexpress LLC Cevipabulin fumarate | 849550-67-0 | 99.9% | 580.89 | 25 MG
Supplier: Medchemexpress LLC 25MGHY14949C
Cevipabulin fumarate is an oral, microtubule-active, antitumor compound that inhibits the binding of [3H]NSC 49842 to tubulin. It exhibits an IC50 of 18-40 nM for cytotoxicity in human tumor cell lines, demonstrating good activity on various cancer cell lines.
- Oral, microtubule-active, antitumor compound
- Inhibits binding of [3H]NSC 49842 to tubulin
- Shows cytotoxicity in human tumor cell lines (IC50 of 18-40 nM)
- Active against ovarian, breast, prostate, and cervical tumors
- Produces sub-G1 nuclei at low concentrations (20-40 nM)
- Causes strong G2-M block at concentrations above 50 nM
- Active in vivo against human tumor xenografts
- Exhibits dose-dependent antitumor activity
- Targets microtubule/tubulin and cell cycle/DNA damage pathways
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