Medchemexpress LLC Cevipabulin fumarate (TTI-237 fumarate) | 849550-67-0 | 99.9% | 580.89 | 1 ML

Supplier:  Medchemexpress LLC HY14949C10MM/1ML

Cevipabulin fumarate (TTI-237 fumarate) is an oral, microtubule-active, antitumor compound. It inhibits the binding of [3H]NSC 49842 to tubulin, with an IC50 of 18-40 nM for cytotoxicity in human tumor cell lines. It is for research use only.

• Inhibits tubulin binding with IC50 values of 18-40 nM in human tumor cells.
• Active against ovarian, breast, prostate, and cervical tumor cell lines.
• Induces sub-G1 nuclei at 20-40 nM and G2-M block above 50 nM.
• Demonstrates in vitro cytotoxicity (IC50 18-40 nM) in human cancer cell lines.
• Active in vivo via i.v. and p.o. administration against human tumor xenografts.
• Shows dose-dependent antitumor activity in mouse xenograft models.

Catalog No. 50-003-60269