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Apexbio Technology LLC CFI-400945 1338806-73-7 10mM (in 1mL DMSO)
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Supplier:  Apexbio Technology LLC C58135.1

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CFI-400945 (CAS 1338806-73-7) is an orally bioavailable inhibitor specifically targeting polo-like kinase 4 (PLK4) a member of the polo-like kinase family involved in centriole duplication and cell cycle control By competitively inhibiting ATP binding to PLK4 CFI-400945 potently suppresses PLK4 catalytic activity (IC50 2 8 nM) and blocks PLK4 autophosphorylation in cellular assays (EC50 12 3 nM) The compound exhibits high selectivity against other polo-like kinases and demonstrates antiproliferative activity in various cancer cell lines Thus CFI-400945 is applied in cancer biology research particularly for studying centrosome regulation and tumor growth inhibition

Catalog No. 50-000-64300


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