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Apexbio Technology LLC CFTRinh-172 307510-92-5 10mM (in 1mL DMSO)
Supplier: Apexbio Technology LLC B14355.1
CFTRinh-172 (CAS 307510-92-5) is a small molecule inhibitor selectively targeting the cystic fibrosis transmembrane conductance regulator (CFTR) a cAMP-activated chloride channel involved in epithelial fluid transport in organs such as lung intestine and pancreas It acts by reversibly and voltage-independently inhibiting CFTR currents with a Ki in the range of 0 3 5 M Experimental studies demonstrate CFTRinh-172 rapidly blocks CFTR-mediated short-circuit currents while exhibiting minimal cross-reactivity towards other channels or transporters In animal models CFTRinh-172 reduces cholera toxin-induced intestinal fluid secretion suggesting potential applications in developing cystic fibrosis models and investigating secretory diarrheal diseases
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