Apexbio Technology LLC CGH 2466 dihydrochloride 1177618-54-0 10mg

Supplier:  Apexbio Technology LLC B702710

CGH 2466 dihydrochloride is a small-molecule antagonist targeting adenosine receptors with inhibitory activities against phosphodiesterase type 4 (PDE4) and p38 mitogen-activated protein kinase (MAPK) It is designed to block adenosine receptor signaling and inhibit key inflammatory enzymes thereby modulating inflammatory pathways CGH 2466 dihydrochloride exerts its biological activity primarily through selective inhibition of the PDE4D isoform (IC50 22 5 nM) and inhibition of p38 MAPK and isoforms (IC50 187 18 nM and 400 38 nM respectively) It shows comparable affinities to CGS15943 for the adenosine A1 A2B and A3 receptors but no activity at the A2A receptor Based on these pharmacological properties CGH 2466 dihydrochloride holds research potential in studies involving inflammatory mechanisms such as allergen-induced eosinophilic airway inflammation models

Catalog No. 50-000-87852