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  8. CGK 733, Tocris Bioscience™

CGK 733, Tocris Bioscience™

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Quantity:
10 mg
50 mg
This item is not returnable. View return policy
905973-89-9
C23H18Cl3FN4O3S
555.83
HLCDNLNLQNYZTK-UHFFFAOYSA-N
2,2-diphenyl-n-2,2,2-trichloro-1-3-4-fluoro-3-nitrophenyl thioureido ethyl acetamide, 2,2-diphenyl-n-2,2,2-trichloro-1-4-fluoro-3-nitrophenyl carbamothioylamino ethyl acetamide, diphenyl acetamidotrichloroethyl fluoronitrophenyl thiourea, unii-l3dgz99qym, 2,2-diphenyl-n-2,2,2-trichloro-1-4-fluoro-3-nitrophenyl carbamothioyl amino ethyl acetamide, l3dgz99qym, d00pxo, diphenyl acetamidotrichloroethyl fluoronitrophenyl thiourea inci
6605258
2,2-diphenyl-N-[2,2,2-trichloro-1-[(4-fluoro-3-nitrophenyl)carbamothioylamino]ethyl]acetamide
C1=CC=C(C=C1)C(C2=CC=CC=C2)C(=O)NC(C(Cl)(Cl)Cl)NC(=S)NC3=CC(=C(C=C3)F)[N+](=O)[O-]
This item is not returnable. View return policy
905973-89-9
C23H18Cl3FN4O3S
555.83
HLCDNLNLQNYZTK-UHFFFAOYSA-N
2,2-diphenyl-n-2,2,2-trichloro-1-3-4-fluoro-3-nitrophenyl thioureido ethyl acetamide, 2,2-diphenyl-n-2,2,2-trichloro-1-4-fluoro-3-nitrophenyl carbamothioylamino ethyl acetamide, diphenyl acetamidotrichloroethyl fluoronitrophenyl thiourea, unii-l3dgz99qym, 2,2-diphenyl-n-2,2,2-trichloro-1-4-fluoro-3-nitrophenyl carbamothioyl amino ethyl acetamide, l3dgz99qym, d00pxo, diphenyl acetamidotrichloroethyl fluoronitrophenyl thiourea inci
6605258
2,2-diphenyl-N-[2,2,2-trichloro-1-[(4-fluoro-3-nitrophenyl)carbamothioylamino]ethyl]acetamide
C1=CC=C(C=C1)C(C2=CC=CC=C2)C(=O)NC(C(Cl)(Cl)Cl)NC(=S)NC3=CC(=C(C=C3)F)[N+](=O)[O-]

Description

Induces apoptosis in prematurely senescent cells

Originally defined as a selective inhibitor of ATR and ATM kinases. Induces cell death in prematurely senescent breast cancer cells. Decreases p21CIP1 levels in premature senescent MCF-7 and HCT-116 cells; also exhibits antiproliferative activity in a range of cancer cell lines. Blocks camptothecin -induced p53 phosphorylation and protects cells from camptothecin-induced apoptosis.
Quantity 50 mg
Formula Weight 555.84
Percent Purity >98%
Chemical Name or Material CGK 733

Safety and Handling

Recommended Storage : Store at +4°C