Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
  1. Home
  2. Products
  3. 501976100

STEMCELL Technologies Chaetocin, Size: 500 µg
SDP

Catalog No. 501976100
Encompass

Chaetocin is a fungal mycotoxin, originally produced by Chaetomium species, that inhibits the lysine-specific histone methyltransferases (HMTs) SU(VAR)3-9 (IC₅₀ = 0.8 μM). HMTs are responsible for methylation of histones, thereby affecting heterochromatinization. Chaetocin is also known to inhibit G9a and DIM5 (IC₅₀ = 2.5 μM and 3 μM respectively; Cherblanc et al.; Greiner et al.). Chaetocin also acts as a competitive substrate and inhibitor of the central oxidative stress remediation enzyme thioredoxin reductase-1 (TrxR1; Km = 4.6 μM) more potently than glutathione reductase or thioredoxin (Tibodeau et al.).CANCER RESEARCH· Induces cellular oxidative stress, selectively killing cancer cells and rapidly-proliferating primary cells (Isham et al.; Spannhoff et al.)· Attenuates the growth of glioma xenografts accompanied by an increase in reactive oxygen species (ROS) production (Dixit et al.).

Catalog No. 50-197-6100 Supplier STEMCELL Technologies Supplier No. 73592
May include imposed supplier surcharges.
Add to Cart
Add to Cart

missing translation for 'validMainframeMsg'

Chaetocin is a fungal mycotoxin, originally produced by Chaetomium species, that inhibits the lysine-specific histone methyltransferases (HMTs) SU(VAR)3-9 (IC₅₀ = 0.8 μM). HMTs are responsible for methylation of histones, thereby affecting heterochromatinization. Chaetocin is also known to inhibit G9a and DIM5 (IC₅₀ = 2.5 μM and 3 μM respectively; Cherblanc et al.; Greiner et al.). Chaetocin also acts as a competitive substrate and inhibitor of the central oxidative stress remediation enzyme thioredoxin reductase-1 (TrxR1; Km = 4.6 μM) more potently than glutathione reductase or thioredoxin (Tibodeau et al.).CANCER RESEARCH· Induces cellular oxidative stress, selectively killing cancer cells and rapidly-proliferating primary cells (Isham et al.; Spannhoff et al.)· Attenuates the growth of glioma xenografts accompanied by an increase in reactive oxygen species (ROS) production (Dixit et al.).

Product Title
Select an issue

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.