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Cayman Chemical ChaetomInIn 2.5mg

Supplier: Cayman Chemical 131352.5 MG

20-carboxy Arachdonc acd (20-COOH-AA) s the major metabolte of 20-HETE that s produced n renal tubular epthelal endothelal and mcrovascular smooth muscle cell cultures Ths -oxdaton converson can take place usng purfed alcohol dehydrogenases three and four or by mcrosomes contanng recombnant human CYP4F3B 14780 Lke 20-HETE 20-COOH-AA nhbts on transport n the kdneys t also produces vasorelaxaton of porcne coronary mcrovessels constrcted wth endotheln 20-COOH-AA bnds to solated lgand bndng domans of peroxsome prolferator-actvated receptor a (PPARa) (Kd 0 87 0 12 UM) and PPARY (Kd 1 7 0 5 UM) and s a dual actvator of PPARa and PPARY n a transently transfected COS-7 cell reporter system 14780
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