Apexbio Technology LLC Chelerythrine Chloride 3895-92-9 5mg

Supplier:  Apexbio Technology LLC A33065

Chelerythrine Chloride (CAS 3895-92-9) is a benzophenanthridine alkaloid widely utilized as a selective antagonist of protein kinase C (PKC) with an IC50 of 0 66 M It acts as a high-specificity inhibitor by targeting the kinase regulatory domain serving as a competitive inhibitor with respect to phosphate receptors and a non-competitive inhibitor toward ATP Chelerythrine also inhibits Bcl-xL inducing apoptosis in mouse embryonic fibroblasts (MEFs) with an IC50 of 1 1 M It activates the JNK1 and p38 pathways via MEKK1 and MKK4 contributing to its pro-apoptotic effects In cellular assays chelerythrine reduces cell viability (MTT IC50 2 6 M) and in animal studies promotes apoptosis through reactive oxygen species generation Its applications extend to research on kinase activity apoptosis antimicrobial activity and anti-inflammatory processes

Catalog No. 50-000-92897