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Medchemexpress LLC Chi-KAT8i5 | 2839860-29-4 | 98.0% | 10 MG
SDP

Supplier:  Medchemexpress LLC HY16842810MG

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CHI-KAT8i5 is a selective, orally active inhibitor of KAT8 (lysine acetyltransferase 8) designed for oncology research. It shows measurable binding to KAT8, inhibits proliferation of esophageal cancer cell lines in vitro, induces dose-dependent apoptosis, and has demonstrated tumor growth suppression in xenograft models.

  • Selective KAT8 inhibition with a measured KD of 19.72 μM.
  • Cellular antiproliferative activity (IC50 2-3 μM) in esophageal cancer cell lines.
  • Induces dose-dependent apoptosis in treated cells.
  • Reduces H4K16ac and c-Myc levels in cellular assays.
  • Demonstrated oral activity and tumor growth suppression in vivo.
  • High DMSO solubility (100 mg/mL) and defined storage recommendations.

Catalog No. 50-002-95144


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