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Medchemexpress LLC CHI-KAT8i5 | 2839860-29-4 | 98.00% | 523.69 | 5 MG
Supplier: Medchemexpress LLC HY1684285MG
CHI-KAT8i5 is a selective, orally active KAT8 inhibitor that induces cancer cell apoptosis and suppresses esophageal squamous cell carcinoma (ESCC) growth by targeting the KAT8/c-Myc signaling pathway. It demonstrates high specificity and anti-proliferative effects in vitro and in vivo.
- Selective, orally active KAT8 inhibitor
- High specificity; does not bind to other HAT family proteins
- Induces cancer cell apoptosis
- Suppresses esophageal squamous cell carcinoma (ESCC) growth
- Targets KAT8/c-Myc signaling pathway
- Demonstrates in vitro anti-proliferative effects against KYSE 30 and KYSE 150 cells
- Represses NPM1 and PPAT transcript expression; decreases H4K16ace and c-Myc levels
- Effective in vivo in suppressing ESCC tumor growth
- Reduces Ki-67, c-Myc expression, and H4K16ace levels in vivo
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