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Apexbio Technology LLC CHIR-124 405168-58-3 5mg
Supplier: Apexbio Technology LLC A83945
CHIR-124 (CAS 405168-58-3) is a selective small-molecule inhibitor of checkpoint kinase 1 (Chk1) with an IC50 of 0 3 nM demonstrating over 2 000-fold selectivity versus Chk2 (IC50 0 7 M) It also inhibits PDGFR and FLT3 with nanomolar potency CHIR-124 abrogates DNA damage-induced S and G2-M cell cycle checkpoints and enhances mitotic cell death particularly in p53-deficient tumor cells In preclinical studies CHIR-124 potentiates the cytotoxicity of topoisomerase I poisons such as camptothecin and irinotecan and increases radiosensitivity in various p53-mutant human tumor models This compound is widely used to investigate DNA damage response mechanisms and potential combination strategies in cancer therapy research
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