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Apexbio Technology LLC CHIR-98014 252935-94-7 50mg
Supplier: Apexbio Technology LLC A839550
CHIR-98014 (CAS 252935-94-7) is a potent inhibitor of glycogen synthase kinase-3 isoforms GSK-3 (IC 0 65 nM) and GSK-3 (IC 0 58 nM) GSK-3 is a serine/threonine kinase implicated in cellular signaling pathways regulating proliferation inflammation metabolism and apoptosis In cell-based assays CHIR-98014 enhances glycogen synthase activity in insulin-responsive models including CHO-IR cells primary rat hepatocytes and skeletal muscle from both insulin-sensitive and insulin-resistant rat models In mouse models it activates the Wnt/ -catenin pathway and lowers hyperglycemia following oral administration CHIR-98014 is widely used in studies investigating GSK-3 function and metabolic or neurodegenerative disease mechanisms
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