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Cell Signaling Technology CHIR-99021, GSK-3 Inhibitor, Lyophilized Powder, 5 mg
SDP

Catalog No. 502050534
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CHIR-99021 is a potent and highly selective inhibitor of glycogen synthase kinase-3β (GSK-3β) and GSK-3α with IC50 values of 6.7 and 10 nM, respectively. By demonstrating >500-fold selectivity for GSK-3 over 20 other protein kinases, this compound is valuable for researching pathways involved in type 1 and type 2 diabetes, where it has been shown to increase beta cell replication in isolated rat islets.

  • Potent inhibition of GSK-3β and GSK-3α
  • High selectivity (>500-fold) for GSK-3
  • Supports research into beta cell replication
  • Supplied as a lyophilized powder
  • Easy reconstitution in DMSO for a 10 mM stock

Catalog No. 50-205-0534 Supplier Cell Signaling Technology Supplier No. 54290S
May include imposed supplier surcharges.
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CHIR-99021 is a potent and highly selective inhibitor of glycogen synthase kinase-3β (GSK-3β) and GSK-3α with IC50 values of 6.7 and 10 nM, respectively. By demonstrating >500-fold selectivity for GSK-3 over 20 other protein kinases, this compound is valuable for researching pathways involved in type 1 and type 2 diabetes, where it has been shown to increase beta cell replication in isolated rat islets.

  • Potent inhibition of GSK-3β and GSK-3α
  • High selectivity (>500-fold) for GSK-3
  • Supports research into beta cell replication
  • Supplied as a lyophilized powder
  • Easy reconstitution in DMSO for a 10 mM stock

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