STEMCELL Technologies CHIR98014, Size: 1 mg

Supplier:  STEMCELL Technologies 73042

Reversibly activate the WNT pathway through inhibition of both isoforms of glycogen synthase kinase 3 (GSK3α and GSK3β) with CHIR98014 (Ring et al. Diabetes, 2003). This WNT pathway activator induces differentiation of endothelial progenitor cells from human induced pluripotent stem cells in the absence of VEGF (Lian et al. Stem Cell Reports, 2014); enhances osteogenic-like differentiation of rat mesenchymal stem cells cultured with high phosphate (Guerrero et al. PLoS One, 2014); and activates glycogen synthase in cells, lowers blood glucose levels and improves glucose disposal in insulin-resistant rats and diabetic db/db mice (Ring et al. Diabetes, 2003). CHIR98014 is supplied as a crystalline solid with ≥98% purity; Molecular weight 486.3 g/mol; CAS Number 556813-39-9. Visit STEMCELL.com for more information and related products.

Catalog No. 50-197-6017