Chloromethyl chloroformate, 97%

Description

CAS: 22128-62-7 | C2H2Cl2O2 | 128.936 g/mol

Chloromethyl chloroformate is used as an intermediate in pharmaceuticals and in manufacture other chemicals. It acts as a reactant in the synthesis of aminocarbonyloxymethyl esters of diclofenac, flufenamic acid and in monomethoxypoly(ethyleneglycol) prodrugs of cyclosporin A.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
Chloromethyl chloroformate is used as an intermediate in pharmaceuticals and in manufacture other chemicals. It acts as a reactant in the synthesis of aminocarbonyloxymethyl esters of diclofenac, flufenamic acid and in monomethoxypoly(ethyleneglycol) prodrugs of cyclosporin A.

Solubility
Slightly miscible with water.

Notes
Incompatible with oxidizing agents and water.

Specifications

Chemical Identifiers

• CAS: 22128-62-7
• Molecular Formula: C2H2Cl2O2
• Molecular Weight (g/mol): 128.936
• MDL Number: MFCD00077688
• InChI Key: JYWJULGYGOLCGW-UHFFFAOYSA-N
• Synonym: chloromethyl chloroformate, chloromethylchloroformate, chloroformic acid chloromethyl ester, carbonochloridic acid, chloromethyl ester, palite, chlormethylchlorformiat, clco2ch2cl, chlormethylchlorocarbonat, chloromethyl choroformate, choromethyl chloroformate
• PubChem CID: 62754
• IUPAC Name: chloromethyl carbonochloridate
• SMILES: C(OC(=O)Cl)Cl

• Melting Point: <-20°C
• Density: 1.465
• Boiling Point: 107°C to 108°C
• Flash Point: 95°C (203°F)
• Odor: Acrid
• Refractive Index: 1.4295
• Linear Formula: ClCO₂CH₂Cl
• Quantity: 10 g
• UN Number: UN2745
• Beilstein: 506426
• Sensitivity: Moisture sensitive
• Solubility Information: Slightly miscible with water.
• Formula Weight: 128.94
• Percent Purity: 97%
• Chemical Name or Material: Chloromethyl chloroformate

Safety and Handling

Hazard Category	H302-H314-H330-H335
Hazard Statement	GHS H Statement H331-H314-H318-H302 Toxic if inhaled. Causes severe skin burns and eye damage. Causes serious eye damage. Harmful if swallowed.
Precautionary Statement	P260-P264b-P270-P271-P280-P284-P303+P361+P353-P304+P340-P305+P351+P338-P310-P330-P331-P363-P501c
DOTInformation	Transport Hazard Class: 6.1; Packing Group: II; Proper Shipping Name: CHLOROMETHYL CHLOROFORMATE
EINECSNumber	244-793-3
TSCA	No
Recommended Storage	Keep cold

SDS

RUO – Research Use Only