Chloromethyl pivalate, 97%, Thermo Scientific Chemicals

Description

Chloromethyl pivalate acts as an intermediate in the synthesis of active pharmaceutical ingredients. It is also involved in the acylation reaction with 9-(2-phosphonylmethoxyethyl)adenine. It serves as a protecting reagent used for the N-protection of amines. It is also employed in the preparation of pivaloyloxy methyl ester of ofloxacin as a prodrug. Further, it is used to prepare sulbactam pivoxil by reaction with sodium salt of sulbactam. In addition to this, it is used as a reagent during the synthesis of an isoindoline-annulated and continuous-flow organic synthesis.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
Chloromethyl pivalate acts as an intermediate in the synthesis of active pharmaceutical ingredients. It is also involved in the acylation reaction with 9-(2-phosphonylmethoxyethyl)adenine. It serves as a protecting reagent used for the N-protection of amines. It is also employed in the preparation of pivaloyloxy methyl ester of ofloxacin as a prodrug. Further, it is used to prepare sulbactam pivoxil by reaction with sodium salt of sulbactam. In addition to this, it is used as a reagent during the synthesis of an isoindoline-annulated and continuous-flow organic synthesis.

Solubility
Miscible with most organic solvents. Immiscible with water.

Notes
Incompatible with strong oxidizing agents.

Specifications

• Density: 1.045
• Boiling Point: 146°C to 148°C
• Flash Point: 40°C (104°F)
• Refractive Index: 1.417
• Linear Formula: (CH₃)₃CCO₂CH₂Cl
• Quantity: 100 g
• UN Number: UN2924
• Beilstein: 1560838
• Solubility Information: Miscible with most organic solvents. Immiscible with water.
• Formula Weight: 150.6
• Percent Purity: 97%
• Chemical Name or Material: Chloromethyl pivalate

Safety and Handling

Hazard Category	H226-H302-H312-H314-H332-H335
Hazard Statement	GHS H Statement H314-H318-H226 Causes severe skin burns and eye damage. Causes serious eye damage. Flammable liquid and vapor.
Precautionary Statement	P210-P233-P235-P240-P241-P242-P243-P260-P264b-P270-P271-P280-P303+P361+P353-P304+P340-P305+P351+P338-P310-P330-P331-P363-P370+P378q-P501c
DOTInformation	Transport Hazard Class: 3; Packing Group: III; Proper Shipping Name: FLAMMABLE LIQUIDS, CORROSIVE, N.O.S.
EINECSNumber	242-735-1
TSCA	Yes
Recommended Storage	Ambient temperatures

SDS

RUO – Research Use Only