Apexbio Technology LLC Chloroquine diphosphate 50-63-5 10mM (in 1mL H2O)

Supplier:  Apexbio Technology LLC A86285.1

Chloroquine diphosphate is an antimalarial agent and inhibitor of TLR7 and TLR9 commonly used in biomedical research to modulate autophagic processes On the cellular level chloroquine diphosphate promotes autophagy through cell cycle arrest at the G1 phase involving increased expression of p27 and p53 and decreased levels of CDK2 and cyclin D1 Additionally chloroquine diphosphate enhances sensitivity of cancer cells toward chemotherapy and radiotherapy treatments by elevating autophagy and apoptotic responses In vitro studies demonstrated dose-dependent activity with reported IC50 values typically ranging from approximately 15 to 40 M depending on cell types This compound is widely utilized as an autophagy modulator and therapeutic adjuvant in tumor cell models

Catalog No. 50-000-61797