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Medchemexpress LLC CHMFL-PI3KD-317 | 2244992-76-3 | 98.0% | 494.03 | 50 MG
Supplier: Medchemexpress LLC HY11260850MG
CHMFL-PI3KD-317 is a highly potent, selective, and orally active PI3Kδ inhibitor. It exhibits high selectivity over other class I, II, and III PIKK family isoforms and effectively inhibits PI3Kδ-mediated Akt T308 phosphorylation. The compound also demonstrates significant antiproliferative effects on various cancer cells and shows favorable oral bioavailability in vivo.
- Highly potent and selective PI3Kδ inhibitor.
- Exhibits over 10-1500 fold selectivity over other PIKK family isoforms.
- Inhibits PI3Kδ-mediated Akt T308 phosphorylation in Raji cells.
- Demonstrates antiproliferative effects on cancer cells.
- Shows favorable oral bioavailability and acceptable half-life in Sprague-Dawley rats.
- Inhibits the growth of MOLM-14 tumors in mice without mortality or significant weight loss.
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