Medchemexpress LLC Chmfl-pi3kd-317 | 2244992-76-3 | 98.0% | 494.03 g/mol | C21H24ClN5O3S2 | 5 MG

Supplier:  Medchemexpress LLC HY1126085MG

CHMFL-PI3KD-317 is a potent, selective, orally active PI3Kδ inhibitor for research use. It inhibits PI3Kδ with an IC50 of 6 nM, blocks PI3Kδ-mediated Akt T308 phosphorylation in cells (EC50 4.3 nM), shows antiproliferative activity in cancer cell lines, and has demonstrated oral bioavailability and tumor growth inhibition in preclinical models.

• Potent PI3Kδ inhibition (IC50 6 nM).
• High selectivity versus other PI3K isoforms (10-1,500x).
• Cellular activity: inhibits Akt T308 phosphorylation (EC50 4.3 nM).
• Demonstrated oral bioavailability and in vivo antitumor efficacy.
• Supplied as a white to off-white solid with suggested storage as powder at -20°C.
• Available in small research pack sizes suitable for preclinical studies.

Catalog No. 50-002-62555