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Medchemexpress LLC CHMFL-PI4K-127 | 2377604-81-2 | C18H15ClN4O3S | 100 MG
SDP

Supplier:  Medchemexpress LLC HY150598100MG

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CHMFL-PI4K-127 (compound 15g) is an orally active, potent, and highly selective PfPI4K (Plasmodium falciparum PI4K kinase) inhibitor with an IC50 of 0.9 nM. It demonstrates potent activity against 3D7 Plasmodium falciparum, exhibiting an EC50 of 25.1 nM. This compound shows antimalaria efficacy, displaying high selectivity against PfPI4K over human lipid and protein kinases. In vivo studies in rodent models demonstrated significant antimalarial activities in a dose-dependent manner, generating curative effects in the blood stage at 80 mg/kg and full protection in the liver stage at 1 mg/kg.

  • Potent and highly selective PfPI4K inhibitor
  • Orally active
  • Shows antimalaria efficacy
  • High selectivity against PfPI4K over human lipid and protein kinases
  • Significant antimalarial activities in rodent models

Catalog No. 50-003-75881


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