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Medchemexpress LLC CHMFL-PI4K-127 | 2377604-81-2 | C18H15ClN4O3S | 50 MG
SDP

Supplier:  Medchemexpress LLC HY15059850MG

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CHMFL-PI4K-127 is an orally active, potent, and highly selective PfPI4K (Plasmodium falciparum PI4K kinase) inhibitor. It demonstrates strong antimalarial efficacy against 3D7 Plasmodium falciparum and drug-resistant strains, showing high selectivity over human kinases.

  • Potent and highly selective PfPI4K inhibitor
  • IC50 of 0.9 nM against PfPI4K
  • Potent activity against 3D7 Plasmodium falciparum (EC50 of 25.1 nM)
  • Effective against drug-resistant strains of P. falciparum (EC50 values of 23-47 nM)
  • Exhibits antimalarial efficacy in both blood and liver stages in rodent models
  • Oral administration of 60 mg/kg daily for 7 days showed suppressive effects in P. yoelii infected mice
  • A single oral dose of 1 mg/kg provided full protection and cure in the liver stage in rodent models

Catalog No. 50-003-75227


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