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Genscript Corporation CHO-K1/5-HT2B Stable Cell Line

Catalog No. 5000058263
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5-Hydroxytryptamine (5-HT also commonly known as serotonin) is synthesized in enterochromaffin cells in the intestine and in serotonergic nerve terminals In the periphery 5-HT mediates gastrointestinal motility platelet aggregation and contraction of blood vessels Many functions of the central nervous system are influenced by 5-HT including sleep motor activity sensory perception arousal and appetite A family of 12 GPCRs and one ion channel mediate the biological effects of 5-HT (Hoyer et al 1994) 5-HT2B which couples to Gq/11 is expressed in embryonic and adult cardiovascular tissues gut and brain from the rat mouse and human species 5-HT2B receptors are responsible for many cardiovascular and central nervous system functions such as blood vessel contraction platelet shape changes neuronal sensitization to tactile stimuli and mediation of the hallucinogenic effects of phenylisopropylamin hallucinogens It has also been shown to be required for heart develo

Catalog No. 50-000-58263 Supplier Genscript Corporation Supplier No. M00249
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5-Hydroxytryptamine (5-HT also commonly known as serotonin) is synthesized in enterochromaffin cells in the intestine and in serotonergic nerve terminals In the periphery 5-HT mediates gastrointestinal motility platelet aggregation and contraction of blood vessels Many functions of the central nervous system are influenced by 5-HT including sleep motor activity sensory perception arousal and appetite A family of 12 GPCRs and one ion channel mediate the biological effects of 5-HT (Hoyer et al 1994) 5-HT2B which couples to Gq/11 is expressed in embryonic and adult cardiovascular tissues gut and brain from the rat mouse and human species 5-HT2B receptors are responsible for many cardiovascular and central nervous system functions such as blood vessel contraction platelet shape changes neuronal sensitization to tactile stimuli and mediation of the hallucinogenic effects of phenylisopropylamin hallucinogens It has also been shown to be required for heart develo

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