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Genscript Corporation CHO-K1/5-HT2C Stable Cell Line
Supplier: Genscript Corporation M00253
5-Hydroxytryptamine (5-HT also commonly known as serotonin) is synthesized in enterochromaffin cells in the intestine and in serotonergic nerve terminals In the periphery 5-HT mediates gastrointestinal motility platelet aggregation and contraction of blood vessels Many functions of the central nervous system are influenced by 5-HT including sleep motor activity sensory perception arousal and appetite A family of 12 GPCRs and one ion channel mediate the biological effects of 5-HT (Hoyer et al 1994) 5-HT2C is expressed in the brain and spinal cord especially the choroid plexus 5-HT2C receptor agonists may have important clinical value in the treatment of mental and eating disorders such as depression panic anxiety OCD bulimia and obesity GenScript s cloned human 5-HT2C-expressing cell line is generated in the CHO-K1 host
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