Genscript Corporation CHO-K1/ADORA3/G15 Stable Cell

Supplier:  Genscript Corporation M00464

Extracellular adenosine mediates a multitude of biological effects including wakefulness antiarrythmia bronchoconstriction and response to ischemia and oxidative stress A family of four G-protein coupled adrenoceptors A1 A2A A2B and A3 is responsible for these effects A3 which couples to G sub i/o /sub is expressed in a wide range of human tissues but most predominantly in the lung and liver Recent animal model studies have shown that A3 receptors play important roles in brain ischemia immunosuppresion and bronchospasm A3 receptor agonists and/or agonists may have important clinical value in the treatment of asthma and inflammation Mice lacking A3 receptors display reduced mast cell degranulation and bronchoconstriction in response to adenosine

Catalog No. 50-000-58053