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Genscript Corporation CHO-K1/CTLA4 Stable Cell Line
Supplier: Genscript Corporation M00530
CTLA4 or CTLA-4 (cytotoxic T-lymphocyte-associated protein 4) also known as CD152 (cluster of differentiation 152) is a protein receptor that functions as an immune checkpoint and downregulates immune responses CTLA4 is constitutively expressed in regulatory T cells but only upregulated in conventional T cells after activation a phenomenon which is particularly notable in cancers It acts as an off switch when bound to CD80 or CD86 on the surface of antigen-presenting cells br/ The CTLA-4 protein is encoded by the Ctla4 gene in mice and the CTLA4 gene in humans
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