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Genscript Corporation CHO-K1/DP1/G15 Stable Cell Li
Supplier: Genscript Corporation M00453
DP1 is a G sub s /sub -coupled GPCR expressed in the colon eye platelets eosinophils that bind to PGD2 and PGE2 DP1 can inhibit platelet aggregation and also inhibit leukotriene B4 and superoxide anion (O2-) release from human neutrophils It can relax smooth muscle and regulate eosinophil apoptosis DP receptor knockout OVA-challenged mice exhibit reduced Th2 cytokine levels and lymphocyte accumulation in the lung In addition they failed to produce asthmatic responses
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