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Genscript Corporation CHO-K1/DP2/G15 Stable Cell Li
Supplier: Genscript Corporation M00436
Prostaglandin D(2) (PGD(2)) is derived from arachidonic acid and binds with high affinity to the G-protein coupled receptors prostanoid DP(1) and DP(2) Interaction with DP(2) results in cell chemotaxis eosinophil degranulation eosinophil shape change adhesion molecule upregulation and Th2 cytokine production In allergic rhinitis and allergic asthma PGD(2) is released from mast cells in response to allergen challenge and may trigger symptoms such as sneezing rhinorrhea pruritus mucus hypersecretion and pulmonary inflammation GenScript s cloned human DP2-expressing cell line co-expressing G 15 is made in the CHO-K1 host
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