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Genscript Corporation CHO-K1/EDNRA Stable Cell Line
Supplier: Genscript Corporation M00149
In mammals the endothelin (ET) family comprises three endogenous isoforms ET-1 ET-2 and ET-3 These endothelium-derived peptides perform their functions via two endothelin receptors classified as EDNRA and EDNRB EDNRA receptors are mainly localized in the vascular smooth muscle cells where they are the predominant sub-type and mediate vasoconstriction and proliferation Selective EDNRA antagonists are effective in the treatment of heart failure essential hypertension pulmonary hypertension and atherosclerosis
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