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Genscript Corporation CHO-K1/LTB4/G15 Stable Cell L
Supplier: Genscript Corporation M00435
The dihydroxy-leukotriene leukotriene B4 (LTB4) is a member of the G protein-coupled receptor (GPCR) family in a subfamily of GPCRs that includes receptors for chemokines and other chemotactic factors Recently a second lower affinity receptor for LTB4 (BLT2) has also been cloned with broader ligand specificity for various eicosanoids LTB4 stimulates neutrophil chemotaxis and secretion but may also affect immunomodulation contraction of certain smooth muscles via an indirect mechanism and activation of the nuclear transcription factor PPAR (peroxisome proliferation activated receptor alpha) Chemotaxis the principal effects of LTB4 and related dihydroxy-acids on leukocytes occurs via activation of BLT1 receptors
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