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Genscript Corporation CHO-K1/mouse HVEM Stable Cell
Supplier: Genscript Corporation M00647
HVEM is found on the surface of various cell types including hematopoietic and non-hematopoietic cells and is expressed mainly in spleen thymus bone marrow lung and intestines It has been identified as a canonical TNF receptor signaling through the TNF receptor-associated factors (TRAFs) leading to NF B activation Furthermore in addition to acting as a signaling receptor in binding to Ig superfamily members it acts as a ligand for these inhibitory receptors Therefore bidirectional signaling is possible for the HVEM-mediated signaling network which can be involved in positive or negative immunological reactions under different contexts
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