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Genscript Corporation CHO-K1/ mouse PD-1 Stable Cell
Supplier: Genscript Corporation M00552
Programmed cell death protein 1 also known as PD-1 and CD279 (cluster of differentiation 279) is a protein that in humans is encoded by the PDCD1 gene PD-1 functioning as an immune checkpoint plays an important role in down regulating the immune system by preventing the activation of T-cells which in turn reduces autoimmunity and promotes self-tolerance The inhibitory effect of PD-1 is accomplished through a dual mechanism of promoting apoptosis (programmed cell death) in antigen specific T-cells in lymph nodes while simultaneously reducing apoptosis in regulatory T cells (suppressor T cells)
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