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Genscript Corporation CHO-K1/NK1 Stable Cell Line
Supplier: Genscript Corporation M00199
Tachykinins are peptides sharing the common C-terminal amino acid sequence Phe-X-Gly-Leu-Met-NH sub 2 /sub This neuropeptide family is composed of substance P neurokinin A and neurokinin B which are widely distributed in mammalian central and peripheral nervous systems It plays a role as both a neurotransmitter and a neuromodulator Their actions are mediated by binding with three distinct receptors namely NK1 NK2 and NK3 NK1 has high affinity with substance P In the CNS NK1 has been implicated to play a role in regulating neuronal survival and degeneration In the cardiovascular system NK1 mediates endothelium-dependent vasodilatation and plasma protein extravasations In the gastrointestinal system NK1 receptors mediate intestinal motility secretion and vascular functions SP-NK1 receptor communication is also involved in glioma development and progression NK1 receptor antagonists may have several therapeutic applications in diseases mediated by tachykinins such as
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