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Genscript Corporation CHO-K1/NK2 Stable Cell Line
Supplier: Genscript Corporation M00200
Tachykinins are peptides sharing a common C-terminal amino acid sequence Phe-X-Gly-Leu-Met-NH sub 2 /sub This neuropeptide family is composed of substance P neurokinin A and neurokinin B which are widely distributed in mammalian central and peripheral nervous systems These three molecules serve as both neurotransmitters and neuromodulators Their actions are mediated by binding with three distinct receptors namely NK1 NK2 and NK3 In particular NK2 is expressed in gastrointestinal tract Activation of NK2 is chiefly responsible for the regulation of intestinal motor functions (both excitatory and inhibitory) secretions inflammation and visceral sensitivity Antagonists of NK2 may be useful in the treatment of irritable bowel syndrome
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