Genscript Corporation CHO-K1/NPY2/Gqi5 Stable Cell L

Supplier:  Genscript Corporation M00460

The NPY family consists of three 36-amino acid peptides neuropeptide Y (NPY) peptide YY (PYY) and pancreatic polypeptide (PP) which bind to the NPY receptors At present five distinct NPY receptors Y1 Y2 Y4 Y5 and y6 have been established by receptor cloning studies and all of them are G sub i /sub -coupled GPCRs Activation of NPY receptors mediate a variety physiological effects including stimulation of food intake inhibition of anxiety in the CNS presynaptic inhibition of neurotransmitter release in the CNS and periphery modulation of circadian rhythm release of pituitary hormones modulation of hippocampal activity pain transmission vasoconstriction inhibition of insulin release and modulation of renal function With regard to endogenous agonists the receptors Y2 preferentially bind NPY and PYY

Catalog No. 50-000-59197