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Genscript Corporation CHO-K1/OX1 Stable Cell Line
Supplier: Genscript Corporation M00224
The orexin/hypocretin peptides orexin A and orexin B (also known as hcrt-1 and hcrt-2) are 33- and 28-amino acid peptides respectively They are preferentially expressed in hypothalamus The orexins have a range of physiological functions including feeding control energy metabolism neuroendocrine function modulation and sleep-wake cycle regulation The two orexin receptor subtypes OX1 and OX2 both mediate the action of orexin-A and orexin-B and couple efficiently through Gq/11 to activate phospholipase C and lead to elevation of intracellular calcium
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