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Genscript Corporation CHO-K1/PAR4 Stable Cell Line
Supplier: Genscript Corporation M00206
Protease-activated receptor (PAR)-4 is a member of a unique family of GPCRs The protease-activated receptors (PARs) that are activated by proteolytic cleavage of the N-terminal domain of the receptor reveal a tethered ligand The PAR family consists of 4 receptors PAR1 and PAR3 are activated by thrombin and PAR2 and PAR4 are activated by several serine proteases (Macfarlane et al 2001) PAR4 is a recently identified low-affinity thrombin receptor that plays a pathophysiological role in many types of tissues including the lung Mice lacking PAR4 are protected from mesenteric arteriole thrombosis indicating that PAR4 is a potential target for treatment of thrombosis in humans
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