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Cayman Chemical Cholesta-3 5-dIen-7-on 10mg
Supplier: Cayman Chemical 3432010 MG
An oxysterol and a negative allosteric modulator of GABAA receptors; reduces GABA-induced currents in HEK cells expressing α1β1γ2 or α4β3γ2 subunit-containing GABAA receptors (IC50s = 1.5 and 1 µM, respectively); reduces GABA-induced depolarization of peptidergic and non-peptidergic nociceptors, C-LTMRs, and cold thermosensors in isolated mouse DRG neurons; increases latency to nocifensive behaviors in the hot plate test in mice at 2, 10, and 50 mg/kg
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