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Cayman Chemical Cholesteryl-d7 PalmItate 10mg
Supplier: Cayman Chemical 900042210 MG
An inhibitor of the protein-microRNA precursor interaction between Lin28 and let-7 binds to the cold-shock domain of Lin28 to inhibit let-7 binding inhibits Lin28-mediated let-7 oligouridylation (IC50 ~27 UM) increases the levels of mature let-7b -7c -7f -7g and -7i as well as the levels of miR-16 which is not regulated by Lin28 at 100 UM in K562 leukemia cells but also increases the levels of miR-16 which is not regulated by Lin28 increases the levels of mature let-7a-i without increasing miR-16 levels in Lin28a/Lin28b double-knockout mESCs expressing exogenous wild-type Lin28a inhibits the protein-protein interaction between PfCoSP and PfDNA or Pfa/B-tubulin is active against P. falciparum strain 3D7 and the chloroquine-resistant strain RKL-9 (IC50s 1.35 and 6.3 nM respectively)
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