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Medchemexpress LLC Cholic acid 7-sulfate | 60320-05-0 | 99.9% | 100 MG
Supplier: Medchemexpress LLC HY126855100MG
Cholic acid 7-sulfate is a selective agonist targeting TGR5 (EC50=0.17 μM) and a ligand for MHC class I-related protein (MR1). It acts as a gut-restricted TGR5 agonist, binding to TGR5 on enteroendocrine L cells, inducing GLP-1 secretion, and improving glucose tolerance in a TGR5-dependent manner. Additionally, it serves as an endogenous ligand for MR1, promoting the survival of mucosal-associated invariant T cells (MAIT) and the expression of homeostatic gene signatures, influencing MAIT cell development and function. It is primarily used in the research of diabetes and MAIT cell-related immune regulation.
- Selective agonist targeting TGR5.
- Ligand for MHC class I-related protein (MR1).
- Induces GLP-1 secretion and improves glucose tolerance.
- Promotes survival of mucosal-associated invariant T cells (MAIT) and expression of homeostatic gene signatures.
- Mainly used for research in diabetes and MAIT cell-related immune regulation.
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