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Medchemexpress LLC Cholic acid 7-sulfate | 60320-05-0 | 99.9% | 25 MG
SDP

Catalog No. 5000341906
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Cholic acid 7-sulfate is a selective agonist targeting TGR5 (EC50=0.17 μM) and a ligand for MHC class I-related protein (MR1). It functions as a gut-restricted TGR5 agonist, binding to TGR5 on enteroendocrine L cells to induce GLP-1 secretion and improve glucose tolerance in a TGR5-dependent manner. Additionally, it acts as an endogenous ligand for MR1, promoting the survival of mucosal-associated invariant T cells (MAIT) and affecting MAIT cell development and function. This compound is primarily used in the research of diabetes and MAIT cell-related immune regulation.

  • Selective agonist targeting TGR5 (EC50=0.17 μM)
  • Ligand for MHC class I-related protein (MR1)
  • Induces GLP-1 secretion
  • Improves glucose tolerance
  • Promotes MAIT cell survival
  • Used in diabetes research
  • Used in MAIT cell-related immune regulation

Catalog No. 50-003-41906 Supplier Medchemexpress LLC Supplier No. 25MGHY126855
May include imposed supplier surcharges.
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Cholic acid 7-sulfate is a selective agonist targeting TGR5 (EC50=0.17 μM) and a ligand for MHC class I-related protein (MR1). It functions as a gut-restricted TGR5 agonist, binding to TGR5 on enteroendocrine L cells to induce GLP-1 secretion and improve glucose tolerance in a TGR5-dependent manner. Additionally, it acts as an endogenous ligand for MR1, promoting the survival of mucosal-associated invariant T cells (MAIT) and affecting MAIT cell development and function. This compound is primarily used in the research of diabetes and MAIT cell-related immune regulation.

  • Selective agonist targeting TGR5 (EC50=0.17 μM)
  • Ligand for MHC class I-related protein (MR1)
  • Induces GLP-1 secretion
  • Improves glucose tolerance
  • Promotes MAIT cell survival
  • Used in diabetes research
  • Used in MAIT cell-related immune regulation

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