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Medchemexpress LLC Cholic acid 7-sulfate (7-Sulfocholic acid) | 60320-05-0 | 99.9% | 50 MG
Supplier: Medchemexpress LLC HY12685550MG
Cholic acid 7-sulfate is a selective agonist targeting TGR5 (EC50=0.17 μM) and a ligand for MHC class I-related protein (MR1). As a gut-restricted TGR5 agonist, it binds to TGR5 on enteroendocrine L cells, induces GLP-1 secretion, and improves glucose tolerance in a TGR5-dependent manner. It also acts as an endogenous ligand for MR1, promoting the survival of mucosal-associated invariant T cells (MAIT) and the expression of homeostatic gene signatures, affecting MAIT cell development and function. It is mainly used in the research of diabetes and MAIT cell-related immune regulation.
- Selective agonist targeting TGR5 (EC50=0.17 μM).
- Ligand for MHC class I-related protein (MR1).
- Binds to TGR5 on enteroendocrine L cells.
- Induces GLP-1 secretion and improves glucose tolerance.
- Promotes survival of mucosal-associated invariant T cells (MAIT).
- Used in research of diabetes and MAIT cell-related immune regulation.
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