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Medchemexpress LLC Chroman 1 dihydrochloride | 1273579-40-0 | C24H30Cl2N4O4 | 1 ML
Supplier: Medchemexpress LLC HY15392A10MM/1ML
Chroman 1 dihydrochloride is a highly potent and selective ROCK inhibitor, demonstrating greater potency against ROCK2 (IC50=1 pM) compared to ROCK1 (IC50=52 pM). It also exhibits inhibitory activity against MRCK, with an IC50 of 150 nM. Research indicates that Chroman 1, at 50 nM over 24 hours, inhibits caspase-3/7 activation and reduces apoptosis in human pluripotent stem cells.
- Highly potent and selective ROCK inhibitor
- More potent against ROCK2 (IC50=1 pM) than ROCK1 (IC50=52 pM)
- Exhibits inhibitory activity against MRCK (IC50=150 nM)
- Inhibits caspase-3/7 activation
- Reduces apoptosis in human pluripotent stem cells
- Formulated as a 10 mM solution in DMSO
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