Chromomycin A3, 97%

Description

CAS: 7059-24-7 | C57H82O26 | 1183.257 g/mol

Chromomycin A3, is used as a G-C specific DNA ligand which inhibits transcription and acts as a DNA binding dye. Chromomycin A3 antagonizes enhanced DNA binding of the transcription factors Sp1 and Sp3 to their cognate G-C box, induced by oxidative stress or DNA damage. Furthermore, by inhibiting transcription, Chromomycin A3 and its structural analogs can inhibit protein biosynthesis.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
Chromomycin A3, is used as a G-C specific DNA ligand which inhibits transcription and acts as a DNA binding dye. Chromomycin A3 antagonizes enhanced DNA binding of the transcription factors Sp1 and Sp3 to their cognate ″G-C&Pr

Specifications

Chemical Identifiers

• CAS: 7059-24-7
• Molecular Formula: C57H82O26
• Molecular Weight (g/mol): 1183.257
• MDL Number: MFCD00043151
• InChI Key: ZYVSOIYQKUDENJ-YVQLHGKOSA-N
• PubChem CID: 23928042
• IUPAC Name: [(2R,3R,4R,6S)-6-[[(6S,7S)-6-[(2S,4R,5R,6R)-4-[(4R,5S,6R)-4-[(2S,4S,5R,6R)-5-acetyloxy-4-hydroxy-4,6-dimethyloxan-2-yl]oxy-5-hydroxy-6-methyloxan-2-yl]oxy-5-hydroxy-6-methyloxan-2-yl]oxy-7-[(1S,3S,4R)-3,4-dihydroxy-1-methoxy-2-oxopentyl]-4,10-dihydroxy-3-
• SMILES: CC1C(C(CC(O1)OC2C(CC3=C(C2=O)C(=C4C(=C3)C=C(C(=C4O)C)OC5CC(C(C(O5)C)OC(=O)C)OC6CC(C(C(O6)C)OC)O)O)C(C(=O)C(C(C)O)O)OC)OC7CC(C(C(O7)C)O)OC8CC(C(C(O8)C)OC(=O)C)(C)O)O

• Type: Chromomycin A3
• Physical Form: Powder
• Melting Point: 185°C (decomposition)
• Color: Yellow
• Quantity: 10 mg
• UN Number: UN3462
• Merck Index: 14,2238
• Solubility Information: Soluble in ethanol,DMSO,and ethyl acetate (10mg/ml).
• Formula Weight: 1183.3
• Percent Purity: 97%
• Chemical Name or Material: Chromomycin A3

Safety and Handling

Hazard Category	H300-H360
Hazard Statement	GHS H Statement H300-H360 Fatal if swallowed. May damage fertility or the unborn child.
Precautionary Statement	P201-P202-P264b-P270-P281-P301+P310-P308+P313-P330-P501c
DOTInformation	Transport Hazard Class: 6.1; Packing Group: I; Proper Shipping Name: TOXINS, EXTRACTED FROM LIVING SOURCES, SOLID, N.O.S.
EINECSNumber	230-348-0
RTECSNumber	GB7875000
TSCA	No
Recommended Storage	Store at -20°C

SDS

RUO – Research Use Only